The Mitchell Reserve was created November 16, 1805, by the Treaty of Mount Dexter between the Choctaw Nation and the United States. It began at a post on the left bank of the Tombigbee River opposite the lower end of the Hatchatigbee Bluff, then ascended the river four miles front and two back, with one-half for the use of Alzira and the other half for Sophia, daughters of Samuel Mitchell by Molly Folsom, a Chaktaw woman. Containing 5,120 acres, the reserve was subject to the same laws and regulations established in the surrounding country. Samuel Mitchell was the U.S. Agent to the Chickasaw Nation. The treaty conveyed vast acres of what is now southeast Mississippi and southwest Alabama to the U.S. and opened Clarke County for settlement. The Mitchell Reserve remains an integral part of the county while retaining a unique position and mystique, and landowners within it have complained of the lack of established land lines because there are no township, range, or section lines.