Jeffcoats' Meeting House, erected as a log structure, served as a Wesleyan meeting house and school at Big Pond Branch, a small community along a branch of the north fork of the Edisto River in an area known as The Indian Head. Founded by English immigrants and missionaries Samuel and William Jeffcoat outside the established townships of Orangeburgh, Amelia, Saxe Gotha, and New Windsor, it stood in an area known to have been inhabited by Native Americans. Bishop Francis Asbury visited the region and the meeting house three times by 1816.