Founded in 1973 in Cambridge, Massachusetts, the Harvard–Smithsonian Center for Astrophysics united Harvard College Observatory and the Smithsonian Astrophysical Observatory, linking institutions whose histories reach back to 1839 and 1890. Building on major earlier achievements in photography, planetary discovery, stellar classification, and the work of Harvard’s women Computers, the center became one of the world’s largest astronomical research institutes. Its scientists helped advance X-ray astronomy through the Einstein and Chandra observatories and contributed to cosmology, galaxy mapping, supernova studies, evidence for supermassive black holes, and early exoplanet research. It also shaped modern astronomy through widely used data systems, software, and observatory partnerships.