Area Presbyterians built a manse in 1920 under the supervision of the Rev. Horace N. Cunningham, and services were held in the building. In January 1921, seven charter members organized First Presbyterian Church. They completed a church building in 1923, and it was replaced in 1951 by a larger church designed by noted area architect and church member William C. Baxter. Members have long worked with the needy, including outreach activities for low-income residents on the U.S.-Mexico border. The congregation also supported organization of the Spanish-speaking San Pablo Presbyterian Church. Today, First Presbyterian Church of Weslaco continues to serve as a spiritual leader in the community.