Settlers mostly from the Lower South, including Alabama, Louisiana, Mississippi, and Georgia, settled this part of Grimes County near John's Creek. By the late 19th century, Blackberry had become a largely African-American settlement. Most families raised livestock and crops such as cotton and corn, and at its peak the community also had a cotton gin, grist mill, and stores. Macedonia Baptist Church dates from 1870; in 1899, William and Martha Burrell sold land to trustees A. W. Ruckett, J. L. Nickerson, and Starling Baker. The church site also served as an African-American school. Blackberry's population has declined since the Great Depression, and the school closed in the 1960s. Many descendants return during Macedonia Baptist Church's annual homecoming.