The First Presbyterian Church of Palacios was organized by the Rev. W.S. Red on June 30, 1907, in the local Methodist Church Pioneer Hall, with eighteen people joining the congregation that day, many of them active in the early growth of Palacios itself. William Clement was elected ruling elder, and founding member Duncan Ruthven was elected mayor when Palacios was incorporated in 1909. A church building was completed at Third and Morton streets in 1910 at a cost of $5,393.02. In May 1911 the congregation called Dr. J.P. Green as its first full-time pastor, and the church was chartered by the State of Texas that November. By 1912 its organizations included the Sunday School, the Westminster League, and a Ladies' Aid and Missionary Society, and that year the congregation established a Mexican mission. An education building was completed in 1948. During World War II, a soldiers' center operated by the church was important to nearby Camp Hulen. A new sanctuary was dedicated in 1951, and the Mexican mission became the second Presbyterian Church of Palacios in 1955. The congregation has long been active in cooperation among religious denominations and in improving racial relations in Palacios. Church women worked toward the desegregation of Palacios public schools in the 1960s and, with Methodist, Catholic, and Baptist churches, members sponsored a multiracial tutorial program. In 1975 the congregation sponsored a Vietnamese family immigrating to the United States. It continues in the traditions of its founders, active in worship and in service to its diverse community and its mission worldwide.