Once a thriving community, Pyron was named for rancher Bob Pyron, who settled on nearby Buffalo Creek before 1890. The first school was held in his cellar. The town was founded in 1900, and in 1910 its citizens moved 4 miles southeast to be on the Santa Fe Railroad. Pyron grew to include a 2-story hotel, an Odd Fellows hall, stores, and a cotton gin, but it declined after a major highway bypassed the site. The post office closed in 1952, and today only the railroad crossing sign and a few houses remain. Old settlers gather yearly at the cemetery to exchange reminiscences.