First Baptist Church of Angleton was established in 1896 with Joseph Matthew Kailin as pastor. A hurricane in 1900 destroyed the sanctuary. Members met in borrowed facilities until 1911, when a new church building was erected. The congregation rebuilt and repaired after each storm and added facilities as membership grew. The church sponsored missions that became Templo Bautista and the Second Baptist Church of Angleton. It supports various outreach ministries and remains an integral part of the community.