Clio's passenger depot was built in 1915 by the Atlantic Coast Line Railway after it absorbed the Florence Railroad, whose branch line had been extended to Clio from Latta in 1895 with a freight depot on South Main Street. A cotton boom drove Clio's dramatic growth between 1900 and 1920, but that prosperity did not survive the Depression. Rail service to Clio ended in 1941, and the tracks along Calhoun Street were removed. The Clio Woman's Club persuaded the town to buy the depot, which has served as a community center and also housed the Woman's Club, Clio Library, and Clio Fire Department. Renovated in 2002, the depot was listed in the National Register of Historic Places in 1979 as part of the Clio Historic District.