Plantation owners began this pineland village in the 1830s to escape lowcountry plantation summer nights thought to cause "country fever" (malaria). By 1844, Pinopolis comprised about 12 homes. The village served as a shelter for refugees during the Civil War. The post office began in 1894 with Elizabeth Ravenel as postmaster. Pinopolis has two Historic Districts listed in the National Register of Historic Places.