Chambers' Creek was named in honor of Thomas Jefferson Chambers (1802-1865), to whom the first land grant within present Ellis County was made in 1834 by the Mexican government. It was also known as Howe's Settlement in honor of William R. Howe, the first settler in the region in 1843. It was an early post office in Robertson County and the first county seat of Navarro County from 1846 to 1848.