Jeromesville, originally spelled Jeromeville, was established on February 14, 1815, on land purchased from Jean Baptiste Jerome by Christian Deardorff, who named the village after Jerome. The area had been inhabited earlier by Native Americans, including Mohican Johnstown, a Mohican village built about 1762 west of the Jerome Fork, where residents cleared bottomland and raised corn. About 1795, Jean Baptiste Jerome, a French Canadian, lived nearby with his Indian wife and daughter, farmed rich bottomland, traded livestock, trapped animals, and had fought with Indians against Mad Anthony Wayne at the Battle of Fallen Timbers. During the War of 1812, after local Indians were forcibly removed, Jerome moved to Huron County, while soldiers under General Reasin Beall cut a road through the village area and a blockhouse under Captain Murray protected settlers during the 1812-1814 uprising. The village later developed schools, beginning with a small log building near the present Jeromesville Cemetery, followed by a two-story frame school, then a brick building after an 1889 fire, an expanded elementary school after enrollment reached 135 students in 1916, and the 1927 building later known as Jeromesville School, now housing Hillsdale Middle School. Richard Hargrave came to Jeromeville in 1818 and opened a tavern said to be the first west of the Allegheny Mountains, operating for 75 years, and the town square included the first Ewing Hardware store, later replaced after fires in 1901 and 1931, while the hardware building on the square remained known first as Carl Hardware and later as Bodager Hardware. Jeromeville also operated a flour mill and sawmill along the Jerome Fork, powered by a dam seen in 1910 and removed in 1912 to prevent flooding; the mill, opened about 1836, was modernized in 1924, received a diesel engine in 1936, produced corn meal and several flours, and closed in 1961. The Great Flood of Ohio inundated the village around the old mill on March 25, 1913, and the Ashland and Wooster Railroad, known as the Rattlesnake Line, later ran through the village and connected with the Pennsylvania. A U.S. Post Office misprint changed the spelling from Jeromeville to Jeromesville, and by 2015 the village remained a community with churches, civic organizations, the Lions Club, American Legion Post 749, Boy Scouts Troop 521, and the Hillsdale School District, whose high school resulted from the 1961 merger of the Jeromesville and Haysville districts and opened in 1965.