A hospital operated at this site from 1905 until it was demolished in 1984. Originally known as Plymire Hospital, it was the home office of Drs. Harry and Brandley Plymire until the residence moved to its present-day location across the street. At that time, it was the only hospital between San Francisco and San Mateo. In 1918, after Harry's death, Dr. Frank S. Dolley built South San Francisco General Hospital, a 42-bed facility that handled industrial injuries and highway accidents. The hospital was sold to Kaiser Permanente in 1953 and became Kaiser Foundation Hospital.