Fort Hill plantation, home of John C. Calhoun and later Thomas Green Clemson, has a rich history tied to Clemson University, the state of South Carolina, and the United States. John C. Calhoun, a former U.S. House of Representative and Secretary of War, served as U.S. Vice President from 1825-1832 and later served as a U.S. Senator and Secretary of State. He married Floride Bonneau Calhoun in 1811, and their daughter Anna Maria Calhoun married Thomas Green Clemson in 1838. After Calhoun's death in 1850, Clemson, a diplomat to Belgium and the first acting U.S. Secretary of Agriculture, controlled and managed the plantation until his death in 1888.