Lozano Plaza occupies the former site of a major Harlingen building begun after Santos Lozano arrived in 1906, bought the second commercial lot on Jackson Street, and put up a small frame building for his general store. In 1915, using a design by Brownsville architect Baltasar Torres, he replaced it with a large two-story structure bearing the inscription S. Lozano and Son on its facade. Over the following decades, the first floor housed the family mercantile store, the town post office, a drug store, C.E. Stone, Kattan's Western Wear, and other businesses, while the upstairs hall served first as a schoolroom and a place for meetings and social gatherings, then as office space, a business school, and a budget hotel. During later refurbishments the facade came to bear the name Pioneer's Building. In February 1981 the building was recognized as a Recorded Texas Historic Landmark, but after it was destroyed by fire in 2004, the City purchased and cleared the property, creating Lozano Plaza. The corner of Jackson and "A" continues to serve as an important community gathering place.