Shottsville and the adjacent area was Chickasaw Indian land until ceded to the U.S. Government by treaty and acts of Congress, after which the U.S. Land Office in Pontotoc, Mississippi sold the land to white settlers. On Oct. 6, 1836, John Stone purchased two 160-acre tracts, and he and his wife, Annie Liles, reared 13 children there. Twelve of those children raised their families in the area known as Stonetown. John Stone's daughter Emma Elvira married Lovid McCindry Shotts in December 1841, and after John Stone's death Lovid and Elvira moved to John's home, opened a store in 1870, and secured a post office in Shottsville in 1874. The first burial at Shottsville was John and Annie Stone's granddaughter in 1840, and in 1846 Annie Stone became the first adult buried there. Honored veterans from the Civil War, WWI, WWII, Korea, Vietnam, and Iraq are buried there, along with many prominent community leaders, including President John Tyler's niece Louise Tyler Stone, who was buried there in 1891.