Founded in 1890 by D.T. Bozeman, a teacher and merchant, on a Main Wagon Road 16 miles northwest of Colorado City, Cuthbert was named for Bozeman's neighbor T.T. Cuthbertson, and Mrs. Bozeman served as its first postmaster. A good well by Bozeman's general store attracted freighters, the first Cuthbert School opened in 1893, and the county's first rural telephone line was built in 1898 from Bozeman's home to Colorado City. In 1907, Cuthbert had Bozeman's Store, C.W. Womack's General Store, a gin, blacksmith shop, barber shop, church, and school. The post office closed in 1959.