Monocacy has long been an important crossroads where routes used by Native Americans, European colonists, and later soldiers shaped travel across the land. Native Americans first lived along the Monocacy River and made foot trails through the forests and along the river. In the 1700s, European colonists followed those trails west, driving out the Piscataway and other tribes, and their growing numbers transformed the trails into turnpikes. In the 1830s, the arrival of the B&O Railroad brought prosperity and made Monocacy Junction a target during the Civil Wars. In the 1950s, construction of Interstate 270 brought new opportunities but destroyed part of the battlefield where some of the heaviest fighting had occurred. On July 9, 1864, Confederate and Union troops fought at Monocacy Junction because the road led to Washington, the railroad could bring troops there, the Monocacy River formed a natural barrier at the bridges and fords, and the high ground offered a strong defensive position. Lt. Gen. Early led 15,000 Confederate troops toward Frederick and the Georgetown Pike, while Maj. Gen. Wallace quickly assembled 3,200 Union troops and rushed them by railroad to Monocacy Junction, where his men used the landscape and river crossings to resist repeated assaults before burning the bridge on the Georgetown Pike.