Long before white settlers, the Indian Lake Region was inhabited by Native American cultures. The Shawnee, Cherokee, and Wyandot were the primary inhabitants, and the Algonquin, Delaware, and Ottawa also had settlements nearby. Many tribes in this area were part of the Lenape culture, having migrated from the New York and Pennsylvania area during colonial times. Recent findings reported Lenape DNA markers in Icelandic Viking lineage, and some evidence suggested that Indian tribes likewise contained Viking DNA. The tribes in this area were predominantly farmers, drawn by natural springs, abundant game, and rich soil. In 1794, General Anthony Wayne defeated Chief Blue Jacket and the allied Indian Nations at Fallen Timbers in northwest Ohio. The resulting Treaty of Greenville gave the Indians land north of a treaty line running through Logan County, while the United States received two-thirds of Ohio. Indians remaining in the area eventually relocated to the Lewistown Reservation, and after additional treaties they were forced to move again to reservations in Kansas and Oklahoma. By 1846, few Indians remained in Ohio. Though they left the area, many landmarks retained names honoring them, and the name Indian Lake reflects their lasting impact on the region.