Francis T. Duffau was among the early settlers who arrived in the late 1950s to farm in this community. The Duffau Post Office was authorized in 1860, and Duffau became a thriving trade center before later declining after several disastrous fires and being bypassed by the railroad. The nearby Duffau mineral wells developed as a health resort that attracted people to the area, and a separate post office operated at Duffau Wells in 1884. H.B. and Eliza Hollis sold land to the Duffau School District in 1884, and the Duffau School merged with Hico schools in 1960. Church of Christ, Baptist, Methodist, and Presbyterian churches served the community for many years. The oldest recorded grave in Duffau Cemetery is that of Nancy Shipman in 1865, and Jacob and N.E. McCarty deeded five acres of land for cemetery purposes in 1874. More than 950 marked graves include those of veterans of the Civil War, World War I, World War II, and the Korean War, as well as members of a number of fraternal organizations. The Duffau Cemetery Association was formed in 1958, and a trust fund was established in 1964 to help maintain the graveyard, which continues to serve Duffau and the surrounding communities.