St. Charles Academy opened in 1882 and was staffed by the Sisters of the Marianites of the Holy Cross. Its original site was at the northeast corner of Ryan and Kirby, part of a Roman Catholic complex of church, convent, and school destroyed in the Great Fire of 1910. In 1913, a new site in the Margaret Place subdivision was selected for St. Charles Academy, where the Sisters constructed a raised two-story red brick building designed by the New Orleans firm of Favrot and Livaudais. The school served all students until Immaculate Conception Elementary School opened in 1950, after which St. Charles Academy served as a high school and boarding school for girls from across Southwest Louisiana. In 1970, St. Charles Academy, Landry Memorial High School, and Sacred Heart High merged to form St. Louis Catholic High School. The St. Charles building then no longer housed students and instead served as a convent for the remaining Marianite Sisters. Much of the Academy building went unused, and it was condemned and demolished in the spring of 1974.