The Nuckolls-Jefferies House was built in 1843 for William Thompson Nuckolls (1801-1855) and was later owned for many years by John D. Jefferies (1838-1910). Built in the Greek Revival style of the antebellum period and later altered in the Neo-Classical style of the post-Civil War era, it is a fine example of a mid-19th century plantation house with significant late-19th century alterations. William T. Nuckolls, a lawyer and politician, represented what was then Spartanburg District in the U.S. House of Representatives from 1827 to 1833. After his death, the house passed through several owners until 1875, when Capt. John D. Jefferies, a Confederate veteran and businessman, acquired it. The house was listed in the National Register of Historic Places in 2007.