The Mazomanie Depot, built in 1857 by the Milwaukee & Mississippi Railroad Company after an earlier depot burned that same year, is the oldest wood frame depot in Wisconsin. In the late nineteenth century, during the height of railroading, Mazomanie was served daily by two eastbound and two westbound passenger trains as well as several freight trains, with special excursion trains carrying passengers to larger cities and draymen delivering freight throughout the village. Mazomanie's first village president, John B. Stickney, served as depot agent from 1856 to 1909, then a record length of employment with the Milwaukee Road. In 1880 the depot was extensively remodeled when its surrounding platform was removed, the building was lowered, and the passenger waiting rooms for men and for women and children were moved from the west end to the east end. As freight traffic declined, the depot was shortened to fifty feet in 1943, and its eaves were cut back by six feet to make room for taller railroad cars. After 116 years of use by the Milwaukee Road, it closed in 1973, was later used for storage, offices, a shop for a community service group, and housing, and in 1993 was restored to its original size and outward appearance for use as the village library and the Mazomanie Historical Society's historical research center.