Founded in Alexandria in 1792 by Quaker pharmacist Edward Stabler, this family apothecary grew from a local shop into a major regional supplier while remaining in Quaker hands for more than a century. Operating on South Fairfax Street, it served customers from local farmers and doctors to figures such as Martha Washington, James Monroe, and Robert E. Lee, selling compounded medicines and many household and medical goods. After passing to William Stabler and then John Leadbeater, the business expanded greatly, endured the Civil War, and later declined as modern drugstores and synthetic medicines reshaped the trade. Preserved after its 1933 bankruptcy, it survives as a rare intact early pharmacy interior.