On May 6, 1821, seven local citizens, including Rev. Cyrus Kingsbury, established the Mayhew Church in the area known as Mayhew Mission. The congregation was received into the Tombeckbee Presbytery in 1829 and moved to Starkville in 1834. Its first sanctuary was built on Louisville Street in 1837. In 1853, the church moved into a new Greek Revival-style building on Main Street. In 1925, the congregation moved into this Neoclassical Revival-style building.