Area Presbyterians built the Manse in 1920 under the supervision of the Rev. Horace N. Cunningham, and services were held there. In January 1921, seven charter members organized First Presbyterian Church. They completed a church building in 1923, and in 1951 it was replaced by a larger church designed by noted area architect and church member William C. Baxter. Members long worked with the needy, including outreach activities for low-income residents on the U.S.-Mexico border, and the congregation also supported organization of the Spanish-speaking San Pablo Presbyterian Church. Today, First Presbyterian Church of Weslaco continues to serve as a spiritual leader in the community.