With help from Rev. O. C. Crow, Methodists in and around Weslaco began organizing into a separate congregation in February 1921. On October 16, 1921, 35 Methodists met to organize their new church, and in November they completed a wooden church building. In 1925, a new red brick church was built, and in 1955 work began across the street to replace it with the present-day sanctuary. The church was instrumental in creating Knapp Memorial Methodist Hospital and Wesley Manor, today John Knox Village, a retirement home. Its outreach work, including an active Sunday School Women's group, music programs, and financial aid to La Santisima Trinidad and La Mesa churches, helped build a stronger community.