The Abenaki village of Mazipskoik, transliterated as Missisquoi, was a focal point of the northern Lake Champlain region from the ancient past through the late 1700s. French settlers began living among the Abenaki in the 1740s, and a Jesuit mission was briefly established in the village. Colonial warfare and land claims resulted in the Abenaki losing much of their land by 1798, but the Abenaki Nation of Missisquoi survived, and many Abenaki live proudly in the area to this day.
