Pastor William Hickman and about 30 people founded Skinquarter Baptist Church in 1778. The first meetinghouse stood east of the church's cemetery. Hickman moved to Kentucky in 1784 and became an early Baptist leader there. Because of anti-missionary sentiment among its members, the congregation left the Middle District Baptist Association and affiliated with the Zoar Association in 1836, but in 1848 it rejoined the Middle District Baptist Association. During the 19th century, five churches were organized from this congregation. Augustus Barton Rudd, a missionary to Mexico and Puerto Rico in the late 19th and 20th centuries, was a member. After a fire in 1890, the current church was initially built in 1891.