Cardwell is a city in southwest Dunklin County, Missouri, United States. The 2024 recorded population is 526. The community was named after Frank Cardwell, an Arkansas banker who lent money to the town's founders. The current mayor of Cardwell is Denise Latting and the current aldermen are Cody Todd, Dustin Lee and Winnia Cohea. Lisa Vowels serves as the City Clerk.

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