Palm River-Clair Mel is a census-designated place (CDP) in Hillsborough County, Florida, United States. The population was 21,024 at the 2010 census, up from 17,589 at the 2000 census. The census area includes the unincorporated communities of Clair-Mel City and Palm River. The ZIP code for Palm River-Clair Mel is 33619.