Guthrie is an unincorporated town and census-designated place (CDP) in and the county seat of King County in the U.S. state of Texas. It is in the northern part of the state, 93 mi east of Lubbock and 117 mi west of Wichita Falls. It serves as the principal headquarters of the Four Sixes Ranch. As of the 2020 census, its population was 151, down from 160 at 2010.