Six Mile is a town in Pickens County, South Carolina, United States. The 2010 census showed a population of 675, representing a 21% increase since 2000. The 2020 census showed a population of 678 representing a 0.30% increase since 2010. The average household income in Six Mile is $82,828 with a poverty rate at 6.54%. The median rental costs in recent years is $618 per month, and the median house value is $258,700