Myrtle Grove is a census-designated place (CDP) in New Hanover County, North Carolina, United States. The population was 11,476 at the 2020 census which is up from 8,875 in 2010. Myrtle Grove is located in the statistical townships of Federal Point and Masonboro. The CDP is part of the Wilmington, NC Metropolitan Statistical Area. Myrtle Grove was first listed as a CDP at the 1980 United States census.