Mayodan is a town in Rockingham County, North Carolina, in the United States. It is a manufacturing site for Sturm, Ruger & Co., Bridgestone Aircraft Tire, and formerly General Tobacco until its closure in 2010. Washington Mills Company, later Tultex, operated a textile mill in Mayodan until 1999. The town is named for two rivers that converge nearby, the Mayo and the Dan, and, according to Ripley's Believe It or Not!, is the only town in the world with this name.

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