Wye is an unincorporated community and census-designated place in Missoula County, Montana, United States. It is part of the Missoula metropolitan area. The population was 714 at the 2020 census, up from 511 in 2010. The community is named for the "y"-shaped DeSmet Junction where US 93 and MT 200 met former US 10 (immediately south of US 10's replacement, I-90).