The Prairie Hill Baptist Church congregation was organized on October 18, 1885, with 12 charter members, and Mount Antioch Baptist Church assisted with the organization and the ordination of deacons through Ezekial Jackson Billington, who had been ordained as a minister by Mount Antioch Church. Billington helped organize a number of churches in the area, including those at Froza, Horn Hill, Hubbard, and Mount Calm. His daughter Madora and her husband, J.R. Leathers, donated land at this site for a church building and cemetery. The first sanctuary was completed in 1890. George L. Jennings, who had served in the Confederate Army during the Civil War and had preached in Mississippi before coming to Texas in 1873, was called as the first pastor of the Prairie Hill congregation. Early members were primarily cotton and corn farmers from the surrounding area. Preaching services were held Sunday mornings and evenings, and a Sunday School program and Bible classes began later. Over the years, the church became an important part of the religious heritage of Limestone County.