Mosby Hill is a summit in Oregon County in southern Missouri, rising 965 feet above sea level and about 455 feet above the junction of Hurricane Creek and the Eleven Point River. The community of Greer lies about 3.5 miles to the southwest along Missouri Route 19. The hill was named for a local merchant known as Mr. Mosby. Its significance rests less in great height than in its prominent position overlooking the nearby meeting of creek and river in the Eleven Point country.