Methodism first came to Millerstown in 1784 through Reverend Simon Pile, a circuit rider in The Juniata Circuit of the Methodist Episcopal Church, with early gatherings probably held in private dwellings or in the open air. In 1832, services moved to a log building near the old Presbyterian Cemetery on South High Street that also served as a school during the week. The congregation built the present church of local mountain stone in 1840, and a white picket fence was installed around the churchyard the next year. In 1876, parishioners excavated a basement for youth and prayer meetings. A major renovation in 1904 raised the roof, removed the double entrance doors, and added a vestibule, steeple, bell tower, and stained glass windows. In 1937, the sanctuary and basement school room were enlarged and inside stairs and two lavatories were added. After a chimney fire in 1940, the church converted from coal to oil. In 1946, members added a side door and steps to Greenwood Street and installed an Allen electronic organ in the sanctuary. Extensive changes came in the late 1960s, including new pulpit furniture and altar railings in 1967. When the Methodist Episcopal and Evangelical United Brethren churches united nationally in 1968, it became the Millerstown United Methodist Church. A new Allen organ replaced the older one in 1971. On July 8, 1990, members broke ground to enlarge the sanctuary and add classrooms, a social hall, and a modern kitchen, and the project was completed in 1991 in time for the church's 150th Anniversary. Today, it is the oldest Millerstown congregation remaining in its original location.