Originally founded in 1613 at Isleta Pueblo in New Mexico and dedicated in 1621 as San Antonio de Isleta, this mission was removed to the El Paso area in 1680 during the Pueblo Revolt by Tigua Indians, who brought along the patron saint as they accompanied fleeing Spaniards, and it was re-established here in 1682. It was named successively Sacramento de Los Tiguas de Ysleta, Corpus Christi de Los Tiguas De Ysleta in 1691, San Antonio de los Tiguas de Ysleta in 1744, and Nuestra Senora del Carmen in 1874. The present chapel has the walls and bells of the 1744 building and still ministers to the Tiguas.