In the 1920s, Prohibition ended wine production, eliminating one of the most profitable businesses in the Cordelia area. Cordelia suffered its worst blow in 1939, when a fire that began in the back of Glashoffs Meat Market burned down much of the town, including the railroad depot. After the fire, the Southern Pacific Railroad chose not to rebuild the depot, and most of the other destroyed buildings were also not replaced. This transportation route helped sustain Cordelia for another decade and a half, but in 1954 Route 40, now Interstate 80, was realigned to bypass the town, and Cordelia never regained its earlier economic prosperity. Before these losses, the community included businesses and public buildings such as Siebe's General Store, the post office, library, barber shop, the meat market with Glashoffs Dance Hall above it, and the depot. The firehouse survived the 1939 fire; it had begun as a livery stable at Cordelia Road and Ritchie Road, was converted into a garage by C.J. Lockefeer in 1919, later became the Cordelia Firehouse, and in 1932 the Cordelia Fire Department joined the Cordelia Fire Protection District established in 1918 to serve Cordelia, Green Valley, Rockville, and Lower Suisun Valley. Lockefeer had come to Solano County in 1917 and helped the fire department acquire its first fire truck, with a 100 gallon water tank, two 40 gallon soda acid extinguishers, and a hose reel mounted on a Reo Truck Company chassis. Peter Siebe Sr., owner of the general store built before 1875, served on the Solano County Board of Supervisors from 1887 to 1895.