Designed by architect James Freret in 1886, this Eastlake-style house was built for Clement Penrose and features oversized brackets with openwork circular motifs. Andrew J. McShane purchased it in 1891 for his widowed Irish mother, Rosa, and sister, Sarah. Remembered for his remarkable work ethic and business acumen, Andrew went to work in his uncle's hide business at age 9, became a salesman at 14, and by 21 was the sole owner, operating under his own name with offices locally and in New York. He served as mayor of New Orleans from 1920 to 1924 and was praised for his anti-corruption ideals. After McShane died in 1936, the home passed to Agnes Bruns MeShane and their only child, Rose Mary McShane Kernan. Rose Mary inherited the home in 1969, and it remains in the family, housing the sixth generation. Though additions have been made to its side-hall camelback shotgun design, the house retains its original details and charm.