Otsego Methodist Church was organized in 1842 and served by a traveling minister. The first church was built on this site in 1847. On December 22, 1889, over 900 townspeople attended the dedication of the present church, and many donated money toward what remained of the $7,500 construction debt. Civil War mapmaker Charles Prentiss designed the church, and Art Stained Glass Works in Chicago made the sanctuary windows.