Darby is a Greek Revival house built for Nathan L. Griffin (1803-1853), a lawyer, planter, and member of the S.C. House from 1838 to 1839 and the S.C. Senate from 1846 to 1853. Griffin’s son-in-law Milledge L. Bonham (1813-1890) lived here with his wife Ann from their marriage in 1845 to 1861. After serving in the S.C. House, Bonham was an officer during the Mexican War and a U.S. Congressman from 1857 to 1860. During the Civil War he was a Confederate general, a C.S. Congressman, and governor of S.C. from 1862 to 1864. In 1863 he sold Darby to George A. Trenholm (1807-1876), Confederate Secretary of the Treasury from 1864 to 1865, whose relative Francis S. Holmes (1815-1882) of the Confederate Nitre and Mining Bureau lived here from 1864 to 1865. Darby was listed in the National Register of Historic Places in 1974.