Pfafftown began as a farming community on the west bank of Muddy Creek around the farm of Peter Pfaff Sr., who purchased the land in 1784. In the mid- to late-1800s, several houses in the Greek Revival and other popular styles were built, and in 1865 the first Pfafftown Christian Church was constructed on Transou Road. Pfafftown received a post office in 1888, and by 1896 its population had grown to 100. In 1891, John Henry Pfaff opened a general store at Yadkinville Road and Pfaff Lane that remained there until 1972. In 1900 the Labor Exchange School was built on Transou Road and for many years provided labor and products of labor within the community. Several mid- and late-nineteenth-century buildings remain.