The DeNayer House is a fine example of transitional Queen Anne and Colonial Revival architecture, with a combination hipped and gabled roof and irregular floorplan characteristic of the Queen Anne style, and corner pilasters and clapboard siding that reveal transitional Colonial Revival elements. In February 1899, Dr. J. B. “Doc” DeNayer returned to Stevensville with his family to reopen his water-powered sawmill on the west side of the Bitterroot River. His wife, Julia, purchased these lots in 1899 and hired local contractor G. L. Martin to build the residence. Construction began the following spring, and the DeNayers moved into their new home in August, 1900. Two years later they built a second residence just north of their home. In 1907, Mrs. DeNayer exchanged these properties for a business building owned by H. F. Hooper and planned to open a restaurant. The property changed hands several times until 1918, when Dr. William P. Reynolds bought the home. Reynolds and his wife, Winifred, were both medical doctors known not only for their medical skill but also for their benevolent care, serving anyone at any time and showing little concern for a patient’s ability to pay. The home remained in the Reynolds family until 1950. Over the years, the residence suffered insensitive alterations, including removal of the original porch, removal of the bay window area on the first floor, and replacement of the wood shake roof with heavy asphalt shingles. Major restoration in the early 1990s returned the home to its former place of honor on Main Street.