Louise was founded in 1881 on the route of the New York, Texas, and Mexican Railway and was named for the daughter of railroad director D.E. Hungerford. It soon became a shipping and marketing center for the area. In 1891, ten years after the town was founded, the Rev. John Ovall, a missionary from Victoria, called a meeting of area Methodists to organize a church. The Louise Methodist Church built its first house of worship in 1893, and for a number of years the building also served as the public schoolhouse and a community gathering place. Moved to this site in 1940, the church structure has undergone several remodeling projects to accommodate the growing congregation. Throughout its history, the church has shared clergy with other churches in its circuit, including those in El Campo, Ganado, Cordele, Lolita, and Garwood. An important part of Louise's history, it continues to serve the community with worship, educational, and outreach programs, and descendants of the congregation's first families remain among its members.