When Methodism first came to this area in the late 18th century, residents worshipped in local homes and traveled to nearby towns for services. On November 20, 1848, William and Sarah Griffith conveyed land at this location to trustees of the Methodist Episcopal Church to build a church or place of worship there. Construction was completed circa 1850, and the building was named in their honor. The chapel is a well-preserved example of a mid-nineteenth-century rural Methodist meeting house, with a plain interior containing a balcony, recessed apse, and original pews. Services were conducted here until the mid-1970s. In 1982, the Peninsula Conference of the United Methodist Church deeded the property to the Williamsville Historical Society. Griffith's Chapel was placed on the National Register of Historic Places in 1983.