The first known burial at Dupree Cemetery is Nancy Vinson Christopher, who died May 16, 1852. Many unmarked fieldstones are present and could mark older graves. The cemetery contains 52 identifiable burials with headstones. Five Confederate soldiers and one World War II veteran are buried there along with other notable citizens including Dr. William J. Dupree and Dr. O.P. Dupree. Family names found there include Christopher, Dunivant, Dunnavant, Dupree, Hare, Hawkins, Jackson, Johnson, Lovell, McCracken, Patterson, Smith, and Vinson. Dupree Cemetery is being preserved by descendants of those buried there, who hope this special place and those buried there are never forgotten. It was listed on the Alabama Historic Cemetery Register on May 23, 2012.