Located near Childress Creek, the Cayote community grew around a grocery store, later known as Cayote Store, established about 1866. The store supplied settlers and drovers herding cattle to markets. In 1879, the store applied for a post office under the name Evans Cross Roads; however, inexplicably the name was changed to Cayote, likely a misspelling of the animal. By the 1880s, prairie settlements increased and the town grew with a school (1884), church (1880s), cotton gin, blacksmith shop and community building. The town thrived until the 1960s when several businesses closed. Today, all that remains of this small rural community is the Methodist church and community building.